linked to brain damage 30 years ago
and campaigners predict class action after failures to mount full-scale
research into warnings left millions of patients at risk. Secret documents
reveal that government-funded experts were warned nearly 30 years ago that
tranquillisers that were later prescribed to millions of people could cause
Medical Research Council (MRC) agreed in 1982 that there should be large-scale
studies to examine the long-term impact of benzodiazepines after research
by a leading psychiatrist showed brain shrinkage in some patients similar
to the effects of long-term alcohol abuse. However, no such work was ever
carried out into the effects of drugs such as Valium, Mogadon and Librium
– and doctors went on prescribing them to patients for anxiety, stress,
insomnia and muscle spasms.
and lawyers described the documents as a scandal, and predicted they could
lead the way to a class action costing millions. There are an estimated
1.5 million "involuntary addicts" in the UK, and scores display
symptoms consistent with brain damage.
MRC hosted a meeting of eminent experts and government representatives in
1981 after research by Malcolm Lader, now emeritus professor of the Institute
of Psychiatry, showed brain shrinkage occurred in some benzodiazepine patients.
to carry out studies to examine long-term problems associated with these
drugs, which GPs prescribed more than 20 million times last year, were accepted
by the MRC Neurosciences Board in January 1982. But then the trail goes
dead. The documents, which have been seen by The Independent on Sunday and
were marked "closed until 2014", do not make it clear why no work
to test Professor Lader's findings properly was ever funded. The Department
of Health has no record of the meeting.
Dobbin, the chairman of the All-Party Parliamentary Group for Involuntary
Tranquilliser Addiction, said: "Many victims have lasting physical,
cognitive and psychological problems even after they have withdrawn. We
are seeking legal advice because we believe these documents are the bombshell
they have been waiting for. The MRC must justify why there was no proper
follow-up to Professor Lader's research, no safety committee, no study,
nothing to further explore the results. We are talking about a huge scandal
Hopkins, the legal director of Action against Medical Accidents, added:
"The failure to carry out research into the effect of benzodiazepines
has exposed huge numbers of people to the risk of brain damage. This research
urgently needs to be carried out, and if the results confirm the suspicions
of the 1981 expert group, it could lead to one of the biggest group actions
for damages against the Government and the MRC ever seen in the courts."
advertised as completely harmless, benzodiazepines ("benzos")
were touted as the world's first wonder drug in the 1960s. Within a decade
they became the UK's most commonly used medication.
guidelines for doctors say they should be prescribed for a maximum of four
weeks. But some people become "involuntarily addicted" within
days, unable to stop without withdrawal symptoms such as burning sensations,
distorted vision, headaches and even fatal seizures.
patients who have taken the pills for months or years have enduring neurological
pain, headaches, cognitive impairment and memory loss. But 30 years after
the MRC first considered the idea, there is no medical research to confirm
whether this is down to drug-induced brain damage or not.
Lader said yesterday: "The results didn't surprise us because we already
knew long-term alcohol use could cause permanent brain changes. There should
have been a really good, large-scale study but I was never given the facilities
or resources to do it.
asked to set up a unit to research benzos but they turned me down... they
could have set-up a special safety committee, but they didn't even do that.
I am not going to speculate why; I was grateful for the support they did
give me. There were always competing interests for the same resources, so
maybe it wasn't regarded as important enough."
the small study and found similar, inconclusive results, but then gave up.
"I was getting on with other research and didn't want to be labelled
as the person who just pushed benzos... I should have been more proactive...
I assumed the prescribing would peter out, but GPs are still swinging them
around like Smarties."
MRC has funded around 20 benzodiazepine studies since 1982, mainly in laboratory
animals, but the critical questions posed by Professor Lader in 1981 remain
Ashton, emeritus professor of clinical psychopharmacology at the University
of Newcastle upon Tyne, set up the first NHS withdrawal clinic in 1984.
In 1995 she submitted a research proposal to the MRC to investigate the
link between long-term benzodiazepine use and permanent brain damage, using
sophisticated EEG and MRI scans, and cognitive testing in a randomised control
trial. Her proposal was rejected.
are a growing number of claims against individual doctors for negligent
prescribing benzodiazepines. Ray Nimmo, prescribed Valium as a muscle relaxant
for stomach pain in 1984, received £40,000 in an out-of-court settlement
in 2002 after 12 years of addiction.
1980s 17,000 claimants began a class action against the pharmaceutical manufacturers
Roche Products and John Wyeth. Procedural delays, technical motions and
escalating costs prevented the cases coming to trial.
group attempted to continue unrepresented as litigants in person but failed.
The manufacturer's total costs, £35m, were awarded, but not enforced
against one of those final litigants, Michael Behan, who now works for Jim
Jones, a solicitor at Leigh Day & Co, said: "We're aware of earlier
litigation against the drug companies which did not succeed. It is interesting
that these documents may well have been pertinent at that time. It seems
rather strange that such information was kept 'hidden' for so long."
spokeswoman said: "The MRC Neurosciences Board accepted the conclusions
of Malcolm Lader's report on benzodiazepines. Therefore the MRC was open
to any research application that met the required scientific standard...
and continues to be receptive to funding in this area. The MRC funds only
the highest quality science as judged by peer review. We do not fund research
which does not meet this quality standard."
Bell, 67 from Surrey, was prescribed lorazepam in 1984 after a panic attack.
She weaned herself off in 2007 but still suffers from neurological pains
in her head, neck and feet. No brain scan has even been done.
was running two florist shops in Essex with my husband; we had a great social
life, and life was generally fantastic. On yet another diet, I had a panic
attack at a party one night. My doctor said there was a wonderful new drug
from the US, so I took it without asking questions. I didn't feel right
straight away. The doctor said it was my illness, increased the dose and
added an anti-depressant. This went on for years, new pill after new pill.
Some days I couldn't even get out of bed.
seen 32 doctors but no one has said it could be the pills; for years I believed
these men in white coats and Armani suits. When I decided enough was enough,
it took me 15 years to come off: five tapered withdrawals made me loopy,
hearing voices, unable even to make tea. No human being should suffer like
this. We lost our home and our businesses. The drugs destroyed our lives."